A9 – Gerhard Hummer

Molecular Simulations of RNA Folding and Function

An emerging challenge in biophysical descriptions of RNA is to elucidate the connection between structure, dynamics and function in vivo. Recent experiments identified unexpected structuring in the RNA transcriptome, indicating regulatory roles for instance in splicing. A major aim of our project is to establish a bridge between secondary-structure prediction and high-resolution structural biology. In a hierarchical formulation using molecular mechanics and simulations, we will first construct extensive ensembles of single-stranded RNA and connect them to NMR, PELDOR and FRET experiments. By combining structured and unstructured segments, we then aim to gain insight into splice regulation on the SMN2 system characterized also experimentally. More

Webpage

Mail

Phone

Hummer Group

gerhard.hummer@biophys.mpg.de

+49 (0) 69 – 6303-2501

Address

Max Planck Institut für Biophysik
Max-von-Laue-Straße 3
60438 Frankfurt am Main

Co-Workers on RNA


Dr. Lukas Stelzl

Postdoc

Email: lukas.stelzl@biophys.mpg.de


Marcel Heinz

PhD. Student

Simulation of chemically modified nucleic acids

Email: marcel.heinz@biophys.mpg.de

Google Scholar


Lisa Pietrek

PhD. Student

Disordered biomolecules, molecular dynamics simulation, biochemistry

Email: lipietre@biophys.mpg.de