Publications

2021

Articles

  1. Samoil Sekulovski, Pascal Devant, Silvia Panizza, Tasos Gogakos, Anda Pitiriciu, Katharina Heitmeier, Ewan Phillip Ramsay, Marie Barth, Carla Schmidt, Thomas Tuschl, Frank Baas, Stefan Weitzer, Javier Martinez, Simon Trowitzsch. Assembly defects of human tRNA splicing endonuclease contribute to impaired pre-tRNA processing in pontocerebellar hypoplasia.. Nature Communications (2021). https://doi.org/10.1038/s41467-021-25870-3

2020

Articles

  1. Subrata Dutta, Jennifer Rühle, Margot Schikora, Nina Deussner-Helfmann, Mike Heilemann, Timofei Zatsepin, Patrick Duchstein, Dirk Zahn, Günther Knör, Andriy Mokhir. Red light-triggered photoreduction on a nucleic acid template. Chemical Communications (2020). http://xlink.rsc.org/?DOI=d0cc03086d
  2. Deniz Streit, Thiruvenkadam Shanmugam, Asen Garbelyanski, Stefan Simm, Enrico Schleiff. The Existence and Localization of Nuclear snoRNAs in Arabidopsis thaliana Revisited. Plants (2020). https://doi.org/10.3390/plants9081016
  3. Robert Brilmayer, Martin Brodrecht, Christoph Kaiser, Hergen Breitzke, Bharti Kumari, Josef Wachtveitl, Gerd Buntkowsky, Annette Andrieu-Brunsen. The Interplay of Nanoconfinement and pH from the Perspective of a Dye-Reporter Molecule. (2020). https://onlinelibrary.wiley.com/doi/full/10.1002/cnma.202000423
  4. Nick Neubacher, Nicholas J. Tobias, Michaela Huber, Xiaofeng Cai, Timo Glatter, Sacha J. Pidot, Timothy P. Stinear, Anna Lena Lütticke, Kai Papenfort, Helge B. Bode. Small RNA directs symbiosis, virulence, and natural products biosynthesis in entomopathogenic bacteria. (2020). https://www.biorxiv.org/content/10.1101/2020.08.24.265355v1
  5. Nürenberg-Goloub, Elina, Hanna Kratzat, Heinemann, Holger, Heuer, André, Kötter, Peter, Berninghausen, Otto, Becker, Thomas, Tampé, Robert, Beckmann, Roland. Molecular analysis of the ribosome recycling factor ABCE1 bound to the 30S post-splitting complex. The EMBO Journal (2020). https://www.embopress.org/doi/abs/10.15252/embj.2019103788
  6. Nick Neubacher, Nicholas J. Tobias, Michaela Huber, Xiaofeng Cai, Timo Glatter, Sacha J. Pidot, Timothy P. Stinear, Anna Lena Lütticke, Kai Papenfort, Helge B. Bode. Symbiosis, virulence and natural-product biosynthesis in entomopathogenic bacteria are regulated by a small RNA. Nature Microbiology (2020). https://doi.org/10.1038/s41564-020-00797-5
  7. Oliver Binas, Jan-Niklas Tants, Stephen A Peter, Robert Janowski, Elena Davydova, Johannes Braun, Dierk Niessing, Harald Schwalbe, Julia. E. Weigand, Andreas Schlundt. Structural basis for the recognition of transiently structured AU-rich elements by Roquin. Nucleic Acids Research (2020). https://doi.org/10.1093/nar/gkaa465
  8. Oliver Binas, Irene Bessi, Harald Schwalbe. Structure Validation of G-Rich RNAs in Noncoding Regions of the Human Genome. (2020). https://doi.org/10.1002/cbic.201900696
  9. Oliver Binas, Tatjana Schamber, Harald Schwalbe. The conformational landscape of transcription intermediates involved in the regulation of the ZMP-sensing riboswitch from Thermosinus carboxydivorans. Nucleic Acids Research (2020). https://doi.org/10.1093/nar/gkaa427
  10. P. Broft, S. Dzatko, M. Krafcikova, Robert Hansel-Hertsch, A. Wacker, Volker Doetsch, L. Trantirek, Harald Schwalbe. In-cell NMR of functional riboswitch aptamers in eukaryotic cells. Angewandte Chemie (2020). https://doi.org/10.1002/ange.202007184
  11. F. Cantini, L. Banci, N. Altincekic, J. K. Bains, K. Dhamotharan, C. Fuks, B. Fürtig, S. L. Gande, B. Hargittay, M. Hengesbach, M. T. Hutchison, S. M. Korn, N. Kubatova, F. Kutz, V. Linhard, F. Löhr, N. Meiser, D. J. Pyper, N. S. Qureshi, C. Richter, K. Saxena. 1H, 13C, and 15N backbone chemical shift assignments of the apo and the ADP-ribose bound forms of the macrodomain of SARS-CoV-2 non-structural protein 3b. (2020). https://doi.org/10.1007/s12104-020-09973-4
  12. Alberto Collauto, Sören von Bülow, Dnyaneshwar B. Gophane, Subham Saha, Lukas S. Stelzl, Gerhard Hummer, Snorri Th. Sigurdsson, Thomas F. Prisner. Compaction of RNA Duplexes in the Cell. (2020). http://doi.org/10.26434/chemrxiv.12192732.v1
  13. Sergio Cruz-León, Nadine Schwierz. Hofmeister Series for Metal-Cation-RNA Interactions:The Interplay of Binding Affinity and Exchange Kinetics. Langmuir (2020). https://doi.org/10.1021/acs.langmuir.0c00851
  14. Boris Fürtig, Eva Marie Oberhauser, Heidi Zetzsche, Dean-Paulos Klötzner, Alexander Heckel, Harald Schwalbe. Refolding through a Linear Transition State Enables Fast Temperature Adaptation of a Translational Riboswitch. Biochemistry (2020). https://doi.org/10.1021/acs.biochem.9b01044
  15. Zoe Grewers, Andreas Krueger. MicroRNA miR-181-A Rheostat for TCR Signaling in Thymic Selection and Peripheral T-Cell Function. International Journal of Molecular Sciences (2020). https://doi.org/10.3390/ijms21176200
  16. Florian C Grau, Jeannine Jaeger, Florian Groher, Beatrix Suess, Yves A Muller. The complex formed between a synthetic RNA aptamer and the transcription repressor TetR is a structural and functional twin of the operator DNA-TetR regulator complex. Nucleic Acids Research (2020). https://doi.org/10.1093/nar/gkaa083
  17. Andreas Hegelein, Diana Müller, Sylvester Gröss, Michael Göbel, Martin Hengesbach, Harald Schwalbe. Genetic Code Expansion Facilitates Position-Selective Labeling of RNA for Biophysical Studies. Chemistry - A European Journal (2020). https://doi.org/10.1002/chem.201904623
  18. Carina Immer, Carolin Hacker, Jens Wohnert. Solution structure and RNA-binding of a minimal ProQ-homolog from Legionella pneumophila (Lpp1663). (2020). https://doi.org/10.1261rna.077354.120
  19. Nicolas Jaé, Stefanie Dimmeler. Noncoding RNAs in Vascular Diseases. Circulation Research (2020). https://doi.org/10.1161/CIRCRESAHA.119.315938
  20. Sophie M. Korn, Karthikeyan Dhamotharan, Boris Fürtig, Martin Hengesbach, Frank Löhr, Nusrat S. Qureshi, Christian Richter, Krishna Saxena, Harald Schwalbe, Jan-Niklas Tants, Julia E. Weigand, Jens Wöhnert, Andreas Schlundt. 1H, 13C, and 15N backbone chemical shift assignments of the nucleic acid-binding domain of SARS-CoV-2 non-structural protein 3e. (2020). https://doi.org/10.1007/s12104-020-09971-6
  21. Heike Kunze-Schumacher, Andreas Krueger. The Role of MicroRNAs in Development and Function of Regulatory T Cells-Lessons for a Better Understanding of MicroRNA Biology. Frontiers in Immunology (2020). https://doi.org/10.3389/fimmu.2020.02185
  22. Nathalie Meiser, Nicole Mench, Martin Hengesbach. RNA secondary structure dependence in METTL3-METTL14 mRNA methylation is modulated by the N-terminal domain of METTL3. Biological Chemistry (2020). https://doi.org/10.1515/hsz-2020-0265
  23. Nathalie Meiser, Christin Fuks, Martin Hengesbach. Cooperative Analysis of Structural Dynamics in RNA-Protein Complexes by Single-Molecule Förster Resonance Energy Transfer Spectroscopy. Molecules (2020). https://doi.org/10.3390/molecules25092057
  24. Diana Müller, Sven Trucks, Harald Schwalbe, Martin Hengesbach. Genetic Code Expansion Facilitates Position-Selective Modification of Nucleic Acids and Proteins. (2020). https://doi.org/10.1002/cplu.202000150
  25. A. Schlundt, M. A. Wirtz, B. Knezic, M. Hengesbach, B. Fürtig, J. E. Weigand, J. Wöhnert, J. Ferner, K. Saxena, A. Wacker, C. Richter, S. Sreeramulu, J. Wirmer-Bartoschek, Harald Schwalbe. Gemeinschaftlich in Krisenzeiten: NMR-Strukturbiologie gegen COVID-19. (2020). https://doi.org/10.1007/s12268-020-1396-0
  26. Andreas Schmidt, Gerd Hanspach, Martin Hengesbach. Structural dynamics govern substrate recruitment and catalytic turnover in H/ACA RNP pseudouridylation. (2020). https://doi.org/10.1080/15476286.2020.1842984
  27. Robbin Schnieders, Bozana Knezic, Heidi Zetzsche, Alexey Sudakov, Tobias Matzel, Christian Richter, Martin Hengesbach, Harald Schwalbe, Boris Fürtig. NMR Spectroscopy of Large Functional RNAs: From Sample Preparation to Low-Gamma Detection. Current Protocols in Nucleic Acid Chemistry (2020). https://doi.org/10.1002/cpnc.116
  28. Nadine Schwierz. Kinetic pathways of water exchange in the first hydration shell of magnesium. The Journal of Chemical Physics (2020). https://doi.org/10.1063/1.5144258

2019

Articles

  1. Marina S. Dietz, Mike Heilemann. Optical super-resolution microscopy unravels the molecular composition of functional protein complexes. Nanoscale (2019). 10.1039/c9nr06364a
  2. Marco Kaiser, Jan Philip Wurm, Birgit Märtens, Udo Bläsi, Denys Pogoryelov, Jens Wöhnert. Crystal structure of the translation recovery factor Trf from Sulfolobus~solfataricus. (2019). 10.1002/2211-5463.12772
  3. Marina S. Dietz, Mike Heilemann. Optical super-resolution microscopy unravels the molecular composition of functional protein complexes. Nanoscale (2019). 10.1039/c9nr06364a
  4. Victoria Aladin, Marc Vogel, Robert Binder, Irene Burghardt, Beatrix Suess, Björn Corzilius. Complex Formation of the Tetracycline-Binding Aptamer Investigated by Specific Cross-Relaxation under DNP. Angewandte Chemie International Edition (2019). 10.1002/anie.201811941
  5. Antje C. Wolter, Angela Pianu, Johannes Kremser, Elisabeth Strebitzer, Robbin Schnieders, Boris Fürtig, Christoph Kreutz, Elke Duchardt-Ferner, Jens Wöhnert. NMR resonance assignments for the GTP-binding RNA aptamer 9-12 in complex with GTP. (2019). 10.1007/s12104-019-09892-z
  6. Tim N Baldering, Jakob T Bullerjahn, Gerhard Hummer, Mike Heilemann, Sebastian Malkusch. Molecule counts in complex oligomers with single-molecule localization microscopy. Journal of Physics D: Applied Physics (2019). 10.1088/1361-6463/ab3b65
  7. Diane Daube, Marc Vogel, Beatrix Suess, Björn Corzilius. Dynamic nuclear polarization on a hybridized hammerhead ribozyme: An explorative study of RNA folding and direct DNP with a paramagnetic metal ion cofactor. Solid State Nuclear Magnetic Resonance (2019). 10.1016/j.ssnmr.2019.04.005
  8. Patricia Müller, Patrick Seyfried, Anton Frühauf, Alexander Heckel. Phosphodiester photo-tethers for the (multi-)cyclic conformational caging of oligonucleotides. (2019). 10.1016/bs.mie.2019.04.019
  9. Antonella Di Liddo, Camila de Oliveira Freitas Machado, Sandra Fischer, Stefanie Ebersberger, Andreas W Heumüller, Julia E Weigand, Michaela Müller-McNicoll, Kathi Zarnack. A combined computational pipeline to detect circular RNAs in human cancer cells under hypoxic stress. Journal of Molecular Cell Biology (2019). https://doi.org/10.1093jmcbmjz094
  10. Nürenberg-Goloub, Elina, Robert Tampé. Ribosome recycling in mRNA translation, quality control, and homeostasis. Biological Chemistry (2019). https://doi.org/10.1515/hsz-2019-0279
  11. Elke Duchardt-Ferner, Michael Juen, Benjamin Bourgeois, Tobias Madl, Christoph Kreutz, Oliver Ohlenschläger, Jens Wöhnert. Structure of an RNA aptamer in complex with the fluorophore tetramethylrhodamine. Nucleic Acids Research (2019). https://doi.org/10.1093nargkz1113
  12. Elke Duchardt-Ferner, Michael Juen, Benjamin Bourgeois, Tobias Madl, Christoph Kreutz, Oliver Ohlenschläger, Jens Wöhnert. Structure of an RNA aptamer in complex with the fluorophore tetramethylrhodamine. Nucleic Acids Research (2019). https://doi.org/10.1093/nar/gkz1113
  13. Marcel Heinz, Nicole Erlenbach, Lukas S Stelzl, Grace Thierolf, Nilesh R Kamble, Snorri Th Sigurdsson, Thomas F Prisner, Gerhard Hummer. High-resolution EPR distance measurements on RNA and DNA with the non-covalent G spin label. Nucleic Acids Research (2019). https://doi.org/10.1093/nar/gkz1096
  14. Robbin Schnieders, Sara Keyhani, Harald Schwalbe, Boris Fürtig. More than Proton Detection-New Avenues for NMR Spectroscopy of RNA. Chemistry - A European Journal (2019). https://doi.org/10.1002/chem.201903355
  15. Jasleen Kaur Bains, Julius Blechar, Vanessa de Jesus, Nathalie Meiser, Heidi Zetzsche, Boris Fürtig, Harald Schwalbe, Martin Hengesbach. Combined smFRET and NMR analysis of riboswitch structural dynamics. Methods (2019). https://doi.org/10.1016/j.ymeth.2018.10.004
  16. Edna Bode, Antje K. Heinrich, Merle Hirschmann, Desalegne Abebew, Yan-Ni Shi, Tien Duy Vo, Frank Wesche, Yi-Ming Shi, Peter Grün, Svenja Simonyi, Nadine Keller, Yvonne Engel, Sebastian Wenski, Reuel Bennet, Sophie Beyer, Iris Bischoff, Anthony Buaya, Sophie Brandt, Ibrahim Cakmak, Harun cCimen, Simone Eckstein. Promoter Activation in Dhfq Mutants as an Efficient Tool for Specialized Metabolite Production Enabling Direct Bioactivity Testing. Angewandte Chemie (2019). https://doi.org/10.1002/ange.201910563
  17. Carolin Böger, Anne-Sophie Hafner, Thomas Schlichthärle, Maximilian T. Strauss, Sebastian Malkusch, Ulrike Endesfelder, Ralf Jungmann, Erin M. Schuman, Mike Heilemann. Super-resolution imaging and estimation of protein copy numbers at single synapses with DNA-point accumulation for imaging in nanoscale topography. Neurophotonics (2019). https://doi.org/10.1117/1.NPh.6.3.035008
  18. Adrien Boussebayle, Daniel Torka, Sandra Ollivaud, Johannes Braun, Cristina Bofill-Bosch, Max Dombrowski, Florian Groher, Kay Hamacher, Beatrix Suess. Next-level riboswitch development-implementation of Capture-SELEX facilitates identification of a new synthetic riboswitch. Nucleic Acids Research (2019). https://doi.org/10.1093/nar/gkz216
  19. Adrien Boussebayle, Florian Groher, Beatrix Suess. RNA-based Capture-SELEX for the selection of small molecule-binding aptamers. Methods (2019). https://doi.org/10.1016/j.ymeth.2019.04.004
  20. Diane Daube, Marc Vogel, Beatrix Suess, Björn Corzilius. Dynamic nuclear polarization on a hybridized hammerhead ribozyme: An explorative study of RNA folding and direct DNP with a paramagnetic metal ion cofactor. Solid State Nuclear Magnetic Resonance (2019). https://doi.org/10.1016/j.ssnmr.2019.04.005
  21. Nikolai Grebenovsky, Larita Luma, Patricia Müller, Alexander Heckel. Introducing LNAzo: More Rigidity for Improved Photocontrol of Oligonucleotide Hybridization. Chemistry - A European Journal (2019). https://doi.org/10.1002/chem.201903240
  22. Henrik Gustmann, Anna-Lena J Segler, Dnyaneshwar B Gophane, Andreas J Reuss, Christian Grünewald, Markus Braun, Julia E Weigand, Snorri Th Sigurdsson, Josef Wachtveitl. Structure guided fluorescence labeling reveals a two-step binding mechanism of neomycin to its RNA aptamer. Nucleic Acids Research (2019). https://doi.org/10.1093/nar/gky1110
  23. Gerd Hanspach, Sven Trucks, Martin Hengesbach. Strategic labelling approaches for RNA single-molecule spectroscopy. (2019). https://doi.org/10.1080/15476286.2019.1593093
  24. Thilo Hetzke, Alice M. Bowen, Marc Vogel, Maximilian Gauger, Beatrix Suess, Thomas F. Prisner. Binding of tetracycline to its aptamer determined by 2D-correlated Mn2+ hyperfine spectroscopy. Journal of Magnetic Resonance (2019). https://doi.org/10.1016/j.jmr.2019.04.011
  25. Jeannine Jaeger, Florian Groher, Jacqueline Stamm, Dieter Spiehl, Johannes Braun, Edgar Dörsam, Beatrix Suess. Characterization and Inkjet Printing of an RNA Aptamer for Paper-Based Biosensing of Ciprofloxacin. Biosensors (2019). https://doi.org/10.3390/bios9010007
  26. Jelena Kovacevic, Denise Palm, Domink Jooss, Daniela Bublak, Stefan Simm, Enrico Schleiff. Co-orthologues of ribosome biogenesis factors in A. thaliana are differentially regulated by transcription factors. Plant Cell Reports (2019). https://doi.org/10.1007/s00299-019-02416-y
  27. Marcin Lyszkiewicz, Samantha J. Winter, Katrin Witzlau, Lisa Föhse, Rebecca Brownlie, Jacek Puchalka, Nikita A. Verheyden, Heike Kunze-Schumacher, Esther Imelmann, Jonas Blume, Solaiman Raha, Takashi Sekiya, Akihiko Yoshimura, Jochen T. Frueh, Evelyn Ullrich, Jochen Huehn, Maximiliano G. Gutierrez, Rose Zamoyska, Natalia Ziketara, Andreas Krueger. miR-181a/b-1 controls thymic selection of Treg cells and tunes their suppressive capacity. (2019). 10.1371/journal.pbio.2006716
  28. Adam A Mol, Florian Groher, Britta Schreiber, Ciaran Rühmkorff, Beatrix Suess. Robust gene expression control in human cells with a novel universal TetR aptamer splicing module. Nucleic Acids Research (2019). https://doi.org/10.1093/nar/gkz753
  29. Patricia Müller, Patrick Seyfried, Anton Frühauf, Alexander Heckel. Phosphodiester photo-tethers for the (multi-)cyclic conformational caging of oligonucleotides. (2019). https://doi.org/10.1016/bs.mie.2019.04.019
  30. Denise Palm, Deniz Streit, Thiruvenkadam Shanmugam, Benjamin L Weis, Maike Ruprecht, Stefan Simm, Enrico Schleiff. Plant-specific ribosome biogenesis factors in Arabidopsis thaliana with essential function in rRNA processing. Nucleic Acids Research (2019). https://doi.org/10.1093/nar/gky1261
  31. Michael Schmidt, Kay Hamacher, Felix Reinhardt, Thea Lotz, Florian Groher, Beatrix Suess, Sven Jager. SICOR: Subgraph Isomorphism Comparison of RNA Secondary Structures. (2019). https://doi.org/10.1109/TCBB.2019.2926711
  32. Robbin Schnieders, Antje C. Wolter, Christian Richter, Jens Wöhnert, Harald Schwalbe, Boris Fürtig. Novel 13C-detected NMR Experiments for the Precise Detection of RNA Structure. Angewandte Chemie International Edition (2019). https://doi.org/10.1002/anie.201904057
  33. Mantian Wang, Jingyi Hou, Michaela Müller-McNicoll, Wei Chen, Erin M. Schuman. Long and Repeat-Rich Intronic Sequences Favor Circular RNA Formation under Conditions of Reduced Spliceosome Activity. (2019). https://doi.org/10.1016/j.isci.2019.08.058
  34. A Katharina Weickhmann, Heiko Keller, Jan P Wurm, Elisabeth Strebitzer, Michael A Juen, Johannes Kremser, Zasha Weinberg, Christoph Kreutz, Elke Duchardt-Ferner, Jens Wöhnert. The structure of the SAM/SAH-binding riboswitch. Nucleic Acids Research (2019). https://doi.org/10.1093/nar/gky1283
  35. Samantha J. Winter, Andreas Krueger. Development of Unconventional T Cells Controlled by MicroRNA. Frontiers in Immunology (2019). https://doi.org/10.3389/fimmu.2019.02520
  36. Samantha J Winter, Heike Kunze-Schumacher, Esther Imelmann, Zoe Grewers, Tabea Osthues, Andreas Krueger. MicroRNA miR-181a/b-1 controls MAIT cell development. Immunology and Cell Biology (2019). https://doi.org/10.1111/imcb.12211