Part A is devoted to the development and optimization of new methods for the investigation of RNA properties and function. These novel tools will be applied to understand the role of specific structural elements and conformational dynamics to induce regulatory functions of RNA, from model systems to riboswitch RNA. The developed tools will also be applied to systems defined in Part B, encompassing important RNA-protein complexes (RNP).
Conformational dynamics of RNA regulation elements studied by NMR spectroscopy
Development and characterization of engineered riboswitches
Structure and conformational flexibility of RNA studied by EPR spectroscopy
Quantitative mapping of synaptic molecules within single neurons using correlated super-resolution and electron microscopy
Molecular Simulations of RNA Folding and Function